- Obstetricians & Gynecologists, Holyoke - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Office Buildings & Parks, Holyoke
- Office Planning & Design, Holyoke
- Office Supplies, Equipment & Office Furniture Stores, Holyoke
- Ophthalmologists, Holyoke - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Holyoke
- Opticians, Holyoke
- Optometrists, Holyoke - Eye Doctors, Physicians & Surgeons (Optometry)
- Organizing Services & Products – Household & Business, Holyoke
- Oriental Restaurants, Holyoke
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- Oriental Rugs, Holyoke
- Ornamental Nursery, Holyoke
- Ornamental Nursery Services, Holyoke
- Orthodox Churches, Holyoke
- Orthopedists, Holyoke - Orthopedic Surgery Doctors, Physicians & Surgeons
- Outdoor & Lawn & Garden Equipment Repair & Service, Holyoke
- Outdoor Equipment & Accessories, Holyoke
- Outdoor Furniture & Patio Furniture, Holyoke - Garden Furniture Stores
- Outerwear Stores, Holyoke - Jackets, Sunglasses, Hats, Caps, Coats, Gloves & More
- Oxygen & Respiratory Equipment & Supplies, Holyoke - Oxygen Concentrator, Tank, Machine, etc
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