- Sandwich Shop Restaurants, Southampton
- Savings & Loan Associations, Southampton
- Savings Banks, Southampton
- Scientific Equipment & Services, Southampton
- Scientific Services, Southampton
- Screen Printing, Southampton
- Secondary Schools, Southampton
- Security Alarm Systems - Home & Business, Southampton
- Security Control Systems & Monitoring, Southampton - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Southampton
- Septic Tank Pumping & Cleaning, Southampton - Septic Systems
- Sheet Metal, Southampton
- Shopping & Shopping Services, Southampton
- Snacks & Desserts, Southampton
- Special Education & Care, Southampton
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- Special Interest Schools Or Instruction, Southampton
- Specialty Animal Services, Southampton
- Specialty Rental Services, Southampton
- Specialty Stores, Southampton
- Sporting Goods Stores, Southampton
- State Government, Southampton
- Steak House Restaurants, Southampton
- Steel & Metal Goods, Southampton - Steel Distributors
- Stone And Glass Products, Southampton
- Surveyor Services, Southampton - Surveying Service
- Surveyors, Southampton
- Sweepers & Scrubbers Industrial, Southampton - Sweeping Service
- Swimming Pool, Sauna & Spa Contractors, Southampton
- Swimming Pools Contractors, Southampton - Install Inground - Above Ground Pools
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