- Sales & Marketing Consultant, Lexington
- Sandwich Shop Restaurants, Lexington
- Satellite Dish Antennas & Equipment Dealers, Lexington
- Satellite TV Service, Lexington
- School - Christian, Lexington
- Scientific Services, Lexington
- Scrap & Waste Machinery, Lexington
- Scrap & Waste Materials, Lexington
- Seafood Restaurants, Lexington
- Secondary Schools, Lexington
- Security & Commodity Brokers, Lexington
- Security Brokers & Dealers, Lexington
- Semiconductors & Equipment, Lexington
- Senior Citizens Information & Services, Lexington
- Sewer & Drain Cleaning & Repair, Lexington - Drain Cleaner & Installation Services
- Shoe Dyers, Lexington
- Shoe Repair Shops, Lexington
- Shoe Stores, Lexington - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Lexington
- Siding Materials, Lexington
- Sleep Disorders Treatment & Information Centers, Lexington
- Sleep Doctors, Lexington - Specialists, Physicians & Surgeons (Sleep Medicine)
- Small Appliances, Lexington
- Snacks & Desserts, Lexington
- Snow Removal Services, Lexington - Snow Plow Service
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- Social Service Organizations Mental Health Services, Lexington
- Social Services & Welfare, Lexington
- Social Workers & Services, Lexington
- Societies & Foundation Associations, Lexington
- Soda Fountain Shops, Lexington
- Special Interest Schools Or Instruction, Lexington
- Specialty Animal Services, Lexington
- Specialty Stores, Lexington
- Speech & Hearing Specialists, Lexington
- Speech Pathologists, Lexington - Speech & Language Therapy
- Sporting & Recreational Camps, Lexington
- Sporting Goods Stores, Lexington
- Sports & Recreational Services, Lexington
- Sportswear Clothing Stores, Lexington - Sports Clothes
- Staffing & Support Services, Lexington
- Stamp Collecting & Coin Dealers , Lexington
- State Government, Lexington
- Steam Cleaner - Commercial & Industrial, Lexington - Steam Cleaning - Upholstery, Floor, Carpet, etc
- Stocks & Bond Brokers, Lexington
- Surveyor Services, Lexington - Surveying Service
- Swimming Pool, Sauna & Spa Contractors, Lexington
- Swimming Pools, Lexington
- Swimming Pools Contractors, Lexington - Install Inground - Above Ground Pools
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Lexington
- Synagogues & Temples, Lexington
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