- Education, Holyoke
- Education & Information Services, Holyoke
- Educational Consultants, Holyoke
- Electric Companies, Holyoke
- Electrical Control Systems & Materials, Holyoke
- Electrical Power Systems, Holyoke
- Electrical Supplies, Parts & Equipment, Holyoke - Wholesale & Manufacturers
- Electricians, Holyoke - Electrical Contractors
- Electronic Commerce - Internet Services, Holyoke - E-Commerce Shopping
- Electronic Games Manufacturers, Holyoke
- Electronics Components, Holyoke
- Electronics Manufacturers, Holyoke
- Electronics Stores, Holyoke
- Elementary Schools, Holyoke
- Embossing, Stamping & Engraving, Holyoke
- Embroidery, Holyoke
- Embroidery & Needlework Materials & Supplies Retail, Holyoke
- Emergency Services, Holyoke
- Emergency Victim Services, Holyoke
- Employment Agencies, Holyoke - Staffing Agencies
- Employment Agencies General Labor, Holyoke
- Employment Opportunities, Holyoke
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- Employment Services, Holyoke
- Energy Conservation Consultants, Holyoke
- Engineer & Architect Services, Holyoke - Engineering & Architecture Service
- Engineering Consultants, Holyoke - Consulting Engineers
- Engravers & Typesetting Printers, Holyoke
- Engraving Machine, Supplies & Equipment, Holyoke
- Entertainment & Recreation, Holyoke
- Entertainment Services, Holyoke
- Environmental Conservation & Ecological Services, Holyoke - Ecosystem Services
- Environmental Consultants, Holyoke - Ecological Consulting
- Environmental Engineers, Holyoke
- Environmental Products, Holyoke
- Environmental Products & Services, Holyoke
- Environmental Services, Holyoke
- Episcopal Churches, Holyoke
- Equipment Installation Contractors, Holyoke
- Ethnic Churches, Holyoke
- Ethnic Restaurants, Holyoke
- European Cuisine, Holyoke
- Excavation Contractors, Holyoke - Excavating - Excavator Companies
- Excavation Equipment, Holyoke - Excavating & Ditching Equipment
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