- Dairy Products - Wholesale & Retail, Holyoke
- Dance Companies, Holyoke
- Day Spas, Holyoke
- Decorating & Designing Services, Holyoke
- Delicatessen Restaurants, Holyoke
- Dental Hygienists, Holyoke
- Dentists, Holyoke
- Department Stores, Holyoke
- Dermatologists, Holyoke - Skin Doctors, Physicians & Surgeons (Dermatology)
- Diabetes Help Groups, Holyoke
- Diabetes Services & Supplies, Holyoke - Educational, Referral & Support Service Centers
- Diesel, Holyoke - Engine Fuels, Oils & Lubricants
- Digital Printing & Imaging Service, Holyoke
- Discount Stores, Holyoke - Clothing, Grocery, Furniture, Etc
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- Disease, Handicap & Disability Services, Organizations & Groups, Holyoke
- Divorce & Family Law Attorneys & Lawyers, Holyoke
- Doctors, Physicians & Surgeons, Holyoke
- Document Imaging & Management, Holyoke
- Dolls & Stuffed Toys Manufacturers, Holyoke
- Donuts, Holyoke
- Drafting Services, Holyoke
- Drapery Blinds & Shades Installation & Repair, Holyoke
- Drinking Establishments, Holyoke
- Driveway Contractors - Build, Repair, Sealing, Holyoke - Driveway Pavers - Concrete, Asphalt, Gravel Paving, etc
- Drugs, Pharmaceutical Products & Toiletries - Wholesale & Manufacturers, Holyoke
- Dry Cleaning & Laundry, Holyoke - Dry Cleaners
- Drywall, Insulation & Plaster Contractors, Holyoke - Installation & Repair Services
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