- Sand Gravel & Aggregate, South Hadley
- Sandwich Shop Restaurants, South Hadley
- Scientific Equipment & Services, South Hadley
- Scientific Services, South Hadley
- Seafood Restaurants, South Hadley
- Security Alarm Systems - Home & Business, South Hadley
- Security Brokers & Dealers, South Hadley
- Security Control Systems & Monitoring, South Hadley - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, South Hadley
- Sewer & Drain Cleaning & Repair, South Hadley - Drain Cleaner & Installation Services
- Shoe Store - More, South Hadley
- Shopping & Shopping Services, South Hadley
- Siding Contractors, South Hadley - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Siding Materials, South Hadley
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- Small Appliances, South Hadley
- Snacks & Desserts, South Hadley
- Social Services & Welfare, South Hadley
- Social Workers & Services, South Hadley
- Sound Systems, Microphones & Equipment, South Hadley
- Special Events & Party Supply Rental, South Hadley
- Special Interest Schools Or Instruction, South Hadley
- Specialty Animal Services, South Hadley
- Specialty Stores, South Hadley
- Sporting Goods Equipment Rental, South Hadley
- Sporting Goods Stores, South Hadley
- Sports & Recreational Services, South Hadley
- Stocks & Bond Brokers, South Hadley
- Sushi Restaurants, South Hadley
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